1P-LSD (1-propionyl-lysergamide) is a synthetic compound from the lysergamide group, structurally related to the well-known LSD-25. This article is for informational purposes only and focuses on the chemical properties, history, scientific applications, and legal status of this substance in the Czech Republic.
What is 1P-LSD?
1P-LSD is an analytical and research chemical belonging to the lysergamide group and chemically derived from LSD (lysergamide). The molecule contains a propionyl group (–CO–CH₂–CH₃) attached to the nitrogen atom at position 1 of the indole ring. This small structural modification affects both the legal status of the compound and its physicochemical properties.
| Property | Description |
|---|---|
| Systematic name | 1-propionyl-D-lysergamide |
| Molecular formula | C₂₃H₂₉N₃O₂ |
| Group | Lysergamides (LSD analogues) |
| Origin | Synthetic derivative of LSD-25 developed for research purposes |
Historical context
1P-LSD first appeared in 2015 as a so-called “research analogue of LSD”. The compound was developed to allow scientists to study the effects of lysergamides without directly handling substances prohibited under international conventions.
In laboratories, it is primarily used for pharmacological, neurochemical, and analytical tests, including research on binding to serotonin receptors (5-HT₂A). The compound is not intended for human consumption, and its use outside of scientific contexts is illegal or legally questionable.
Legal status of 1P-LSD in the Czech Republic
As of October 2025, 1P-LSD is not explicitly listed among controlled substances under Czech Act No. 167/1998 Coll., on Addictive Substances. However, due to its chemical similarity to LSD-25, it may be considered an analogue of a controlled substance or subject to individual legal assessment under Section 289 of the Criminal Code.
Recommendation: Any entity handling the substance should have a clearly defined purpose of use (scientific, analytical, research) and maintain documentation proving legal acquisition and use.
Scientific and analytical significance
Substances like 1P-LSD are of interest to scientists, particularly in the study of serotonin receptor pharmacodynamics and their impact on human perception. These studies help to understand the mechanisms of psychedelic action without promoting their use outside controlled environments.
Safety principles and ethical framework
- The substance is not intended for consumption or any form of application to the human body.
- It should be handled only in a controlled laboratory environment.
- When working with the substance, proper safety and occupational regulations must be followed.
This information concerns substances that may be used for scientific or analytical research. All substances must be used solely for scientific, research, analytical, or technical purposes. They are not intended for consumption, application to the human body, or recreational use. Sale to persons under 18 years of age is strictly prohibited. Keep out of reach of children. The entity using the substance is responsible for complying with all applicable legal regulations.